IN-HOSPITAL CARDIAC ARREST OUTCOMES IN ADULT PATIENT WITH INHERITED THROMBOPHILIA: A STUDY OF THE US NATIONAL INPATIENT SAMPLE

TOPIC: Critical Care TYPE: Original Investigations PURPOSE: There is increased evidence suggests that inherited thrombophilia associated with higher risk of arterial thromboembolism, such as myocardial infarction and ischemic stroke. The previous study showed no association between out-of-hospital cardiac arrest. We aim to investigate the outcomes after in-hospital arrest (IHCA). METHODS: A retrospective analysis National Inpatient Sample (2016-2018 data year) was performed. All cases age above 18 were included. IHCA, (Factor V Leiden/activated protein C resistance, prothrombin mutation, deficiencies antithrombin III, C, S), other conditions identified International Classification Diseases, 10th Revision. Continuous variables compared using Welch two sample T-test. Categorical analyzed Pearson's Chi-squared test. Comorbidities adjusted Age-adjusted Charlson Comorbidity Index (CCI). independent factors determined by weighted multivariable logistic regression. RESULTS: 67,351 adult hospitalizations IHCA identified. Among them, 620 patients had thrombophilia. significant younger (mean age: 60.6 vs 65.9, p value < 10-13) fewer comorbidities CCI: 5.32 5.81, <0.0005). difference in gender ethical groups distribution. mortality (Odds ratio (OR): 0.98, = 0.75). Further subgroup revealed III deficiency group significantly (OR: 1.40, 0.05). On contrary, factor Leiden C/S a weak lower 0.70, 0.1; OR: 0.80, 0.06). Antithrombin found severe sepsis 1.56, 0.005). Myocardial infarction, stroke, pulmonary embolism, deep venous thrombosis not for confounders. CONCLUSIONS: Inherited developed underlying at age. While mortality, tendency favorable outcomes. cannot be explained thrombosis. Higher also noted. reason unknown but could play an important role immune response critically ill patients. CLINICAL IMPLICATIONS: similar or without sepsis. required elucidate mechanism. DISCLOSURES: No relevant relationships Tien-Chan Hsieh, source=Web Response Gin Yi Lee, Pramuditha Rajapakse, Guangchen Zou,